brent.j.dill

Comment Threads

• Greg. Tingey commented on How To Survive A Death March
  Could it be that (moderate) exercise, flexing & stretching muscles etc, improves the rate at which fatigue poisons are "flushed out" from the syatem? Just a thought....
• Greg. Tingey commented on How To Survive A Death March
  or use your vacation (all time off is "vacation time", including sick time). Really? Anyone try that here, they would be lucky not to be fined into the ground, with lots of lovely publicty....
• Trottelreiner commented on How To Survive A Death March
  Hm, the substances I know that come closest to "fatigue poisons" would be adenosine, with possible effects of some prostaglandines and other eicosanoids(leukotrienes and like). Where my personal favourite way of dealing with adenosine is still competitive neutral (or inverse?) antagonism, aka caffeine, of course. Problem is, all of these are also created by exercise; on another note, that would indicate some cross-reactions with exercise and caffeine or NSAIDs, at least the somewhat more COX-selective ones. My personal take? Well, as already said, I guess the short-term boost by the usual catecholamines, e.g. adrenaline and noradrenaline, is to blame. Also,...
• Trottelreiner commented on How To Survive A Death March
  How about dopamine? Is that still tied to exercise and improved learning, cognitive performance Quite likely, if nothing else because dopamine is tied with about anything; I guess it's somewhat tied to opposite, e.g. sleeping (Parkinson's leads quite often to sleeping problems) or impaired learning and cognitive performance (some dopamine agonists can have funny behavioural effects, like gambling). What exactly happens depends on a plethora of factors, for starters, there are at least five dopamine receptors, not counting splice variants, http://en.wikipedia.org/wiki/Dopamine_receptor with different affinities and sometimes opposite effects on second messengers. And then, these same receptors are part of neuronal...
• keith.duddy commented on How To Survive A Death March
  It sounds to me like you're really talking about "severe deadline", rather than deathmarches as I understand them... doomed projects where people are forced to go through the motions of proving that despite inhuman effort, the deliverable is not possible by the deadline... http://en.wikipedia.org/wiki/Death_march_(project_management) |<...